Corticosteroids In Treatment Of Bronchial Asthma

Corticosteroids (glucocorticoid hormones) have a strong action but give mass of side effects. Therefore they are applied at rather serious illnesses and states when other medicines are not effective.

In treatment of bronchial asthma corticosteroids are used as inhalations at medium severe form, prescribed inside and intravenously at the asthmatic status and long-term bronchospasm. Steroid hormones don’t expand bronchi.

Indications to application of corticosteroids are: asthmatic status, long-term course and serious attacks of bronchial asthma, cases when bronchodilators are not effective.

Usual doses of corticosteroids:

- Prednisolone is prescribed to adult inside for 40-60 mg once per day, to children for 1-2 mg per day per kilogram of weight within 3-7 days.

- Hydrocortisone is injected intravenously for 200 mg every 4-6 hours to the adult, for 4-6 mg on kilogram of weight to children.

It is possible to increase a dose of corticosteroids if the improvement doesn’t come within a day from the beginning of treatment.

Inhalations corticosteroids are not soaked up in blood from bronchi therefore don’t possess systemic action on organism. At treatment of bronchial asthma they are applied in combination with bronchodilators, and at long-term disease – independently.

It is necessary to gargle mouth and throat with water after each inhalation to avoid mouth candidiasis (thrush caused by yeast funguses) and irritation in throat.

Mouth candidiasis, irritation in throat and hoarseness are side effects of inhalation corticosteroids. They disappear at dose decrease or after cancellation of medicines. Use of buffer nozzles reduces local side effects. After long-term treatment with corticosteroids the dose is gradually reduced.

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